Systemic Inflammation after Aneurysmal Subarachnoid Hemorrhage

Int J Mol Sci. 2023 Jun 30;24(13):10943. doi: 10.3390/ijms241310943.


Aneurysmal subarachnoid hemorrhage (aSAH) is one of the most severe neurological disorders, with a high mortality rate and severe disabling functional sequelae. Systemic inflammation following hemorrhagic stroke may play an important role in mediating intracranial and extracranial tissue damage. Previous studies showed that various systemic inflammatory biomarkers might be useful in predicting clinical outcomes. Anti-inflammatory treatment might be a promising therapeutic approach for improving the prognosis of patients with aSAH. This review summarizes the complicated interactions between the nervous system and the immune system.

Keywords: cerebral aneurysm; subarachnoid hemorrhage; systemic inflammation.

Publication types

  • Review

MeSH terms

  • Biomarkers
  • Hemorrhagic Stroke*
  • Humans
  • Inflammation / complications
  • Intracranial Aneurysm* / complications
  • Subarachnoid Hemorrhage* / etiology


  • Biomarkers

Grants and funding

This research received no external funding.