Liquid Biopsy, a Potential New Detection Method in Heart Allograft Rejection

Chenghao Li; Guohua Wang

doi:10.1007/978-1-0716-3346-5_21

Liquid Biopsy, a Potential New Detection Method in Heart Allograft Rejection

Methods Mol Biol. 2023:2695:309-315. doi: 10.1007/978-1-0716-3346-5_21.

Authors

Chenghao Li¹, Guohua Wang²

Affiliations

¹ Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. guohua_wang@hust.edu.cn.

PMID: 37450128
DOI: 10.1007/978-1-0716-3346-5_21

Abstract

Allografts rejection remains the most important reason causing allograft dysfunction in heart transplantation recipients. Currently, the golden standard for detecting graft rejection is endomyocardial biopsy (EMB). As a new noninvasive technique, liquid biopsy emerges along with the great developments of droplet-based digital PCR and the various optimizations of next-generation sequencing technologies, which is also cheaper than EMB. This review introduces several types of liquid biopsy and its application in heart transplantation.

Keywords: Allograft rejection; Endomyocardial biopsy; Graft-versus-host disease (GVHD); Heart failure; Heart transplantation; Major histocompatibility complex (MHC); Piwi-interacting RNA (piRNA); Transfer RNA (tRNA).

Publication types

Review

MeSH terms

Allografts
Biopsy
Graft Rejection / diagnosis
Graft Rejection / pathology
Heart Transplantation* / adverse effects
Liquid Biopsy
Myocardium / pathology
Transplantation, Homologous