Clinical Effectiveness of Single Lumbar Periradicular Infiltration in Patients with Sciatica

Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2023 Jul 15;44(2):149-156. doi: 10.2478/prilozi-2023-0034. Print 2023 Jul 1.


Periradicular therapy (PRT) is a minimally invasive radiological procedurein patients with chronic lumbar pain.The aim of the study is to identify clinical and radiological predictive factors for treatment success after a single PRT treatment in patients with sciatica.The study includes a prospective follow-up of 166 patients treated with PRT. The pain intensity is determined according to the VAS scale and the degree of improvement is presented as excellent (over 75%), good (50-70%), moderate (25-49%), and weak (less than 25%). The follow up of the treated patients was done at 2 weeks, 3 and 6 months. In patients with pain duration up to 3 months, the improvement was excellent in n=32 (58.18%) after 2 weeks, after 3 months n=41 (74.55%) and after 6 months n=41 (74.55%). This stands in contrast to patients with pain over 1 year. The percentage of improvement after 6 months, post-intervention, was highest in patients without nerve root compression (86.25±19.2),and the highest improvement after 6 months was in patients with localization of pain at the L4-L5 level (69.69±29.7), the greatest improvement after six months was in patients with extraforaminal hernia (62.82±34.3), and the lowest in patients with central stenosis (40.21±30.7).Our study results suggest that the shorter a pain duration, low-grade root compression, injection level and type of herniation area predictor the more favourable response patients have to transforaminal epidural steroid injection in patients with sciatica.

Keywords: MRI; epidural; pain; radiculopathy; steroid.

MeSH terms

  • Humans
  • Injections, Epidural
  • Intervertebral Disc Displacement* / complications
  • Intervertebral Disc Displacement* / diagnostic imaging
  • Intervertebral Disc Displacement* / drug therapy
  • Lumbar Vertebrae / diagnostic imaging
  • Pain / drug therapy
  • Prospective Studies
  • Sciatica* / drug therapy
  • Sciatica* / etiology
  • Steroids / therapeutic use
  • Treatment Outcome


  • Steroids