Plasmablastic Lymphoma: Past, Present, and Future

Clin Lymphoma Myeloma Leuk. 2023 Sep;23(9):e253-e259. doi: 10.1016/j.clml.2023.05.014. Epub 2023 Jun 14.


Plasmablastic Lymphoma is a rare large B-cell lymphoma with unique immunohistochemical and morphological features. It was most commonly associated with HIV infection; however, it's now seen in other immunosuppressed states like autoimmune conditions, post-transplant settings, and even in elderly immunocompetent individuals. Although rare, it is an aggressive lymphoma with unfavorable outcomes. The aim of this manuscript is to have an in-depth review of the current knowledge of epidemiology, pathophysiology, prognostic markers, and treatment approaches currently in use and in clinical trials for this challenging disease.

Keywords: BCMA; CART; Daratumumab; HIV; Immunotherapy.

Publication types

  • Review

MeSH terms

  • Aged
  • HIV Infections* / complications
  • HIV Infections* / epidemiology
  • Humans
  • Lymphoma, Large B-Cell, Diffuse* / drug therapy
  • Plasmablastic Lymphoma* / diagnosis
  • Plasmablastic Lymphoma* / therapy