Role of circulating CD14++CD16+ monocytes and VEGF-B186 in formation of collateral circulation in patients with hyperacute AMI

He Zhang; Shi-Lei Wang; Tao Sun; Jia Liu; Ping Li; Jing-Ci Yang; Fang Gao

doi:10.1016/j.heliyon.2023.e17692

Role of circulating CD14++CD16⁺ monocytes and VEGF-B186 in formation of collateral circulation in patients with hyperacute AMI

Heliyon. 2023 Jun 29;9(7):e17692. doi: 10.1016/j.heliyon.2023.e17692. eCollection 2023 Jul.

Authors

He Zhang¹, Shi-Lei Wang², Tao Sun³, Jia Liu⁴, Ping Li⁵, Jing-Ci Yang⁶, Fang Gao⁷

Affiliations

¹ Department of Cardiology, The Third Hospital of Shijiazhuang City, Shijiazhuang, 050000, China.
² Catheter Lab, The Third Hospital of Shijiazhuang City, Shijiazhuang, 050000, China.
³ Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University Beijing, 100011, China.
⁴ Department of Cardiology, Hebei Provincial People's Hospital, Shijiazhuang, 050000, China.
⁵ Department of Medical Affairs, The Third Hospital of Shijiazhuang City, Shijiazhuang, 050000, China.
⁶ Department of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China.
⁷ Department of Infectious Diseases, The Third Hospital of Shijiazhuang City, Shijiazhuang, 050000, China.

Abstract

Introduction: Collateral formation is insufficient in some patients with acute myocardial infarction (AMI). Peripheral blood CD14++CD16⁺ monocytes (intermediate monocytes; IM) and vascular endothelial growth factors (VEGFs) are associated with formation of collateral circulation.

Methods: We enrolled 49 patients with AMI who underwent emergency percutaneous transluminal coronary intervention (PCI) (Group A) and 27 patients underwent delayed PCI 1 week after AMI (Group B). The percentage of circulating IM and levels of VEGFs in circulation were determined on day 8th. Left ventricular ejection fraction (LVEF) was measured 3 months after AMI.

Results: The peripheral levels of IM and serum VEGF levels on day 8th were significantly higher in patients with well-developed collateral circulation in Group A than those in Group B. The levels of circulating VEGFs in the collateral circulation (+) subgroup in Group B were lower than those in the collateral circulation (-) subgroup. Moreover, the serum VEGF-B186 levels positively correlated with IM.

Conclusions: Hyperacute collateral formation in patients with AMI correlated with a higher percentage of CD14++CD16⁺ monocytes and VEGF-B186 levels in the circulation, which was associated with milder left ventricular remodeling. The regulation of CD14++CD16⁺ monocytes and VEGF-B may be critical to the formation of collateral circulation and to healing AMI.

Keywords: Acute myocardial infarction; CD14++CD16+ monocytes; Collateral circulation; Left ventricular remodeling; Vascular endothelial growth factor.