Ent-kaurane diterpenoids from the Annonaceae family: a review of research progress and call for further research

Traore S Ibrahim; Purevdulam Khongorzul; Moses Muyaba; Raphael N Alolga

doi:10.3389/fphar.2023.1227574

Ent-kaurane diterpenoids from the Annonaceae family: a review of research progress and call for further research

Front Pharmacol. 2023 Jun 29:14:1227574. doi: 10.3389/fphar.2023.1227574. eCollection 2023.

Authors

Traore S Ibrahim¹, Purevdulam Khongorzul¹, Moses Muyaba², Raphael N Alolga¹

Affiliations

¹ Department of Pharmacognosy, State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
² Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, Eden University, Lusaka, Zambia.

Abstract

The Annonaceae is one of the plant families with members that are credited with numerous pharmacological functions. Among the group of compounds responsible for these bioactivities are the ent-kaurane diterpenoids. The ent-kauranes are a group of 20-Carbon, tetracyclic diterpenoids that are widely distributed in other plant families including the Annonaceae family. This mini-review focuses mainly on the ent-kaurane diterpenoids isolated from the Annonaceae family, delineates the various biological activities of these compounds, and highlights the research gaps that exist for further scientific scrutiny.

Keywords: Annonaceae; biological activity; biosynthesis; ent-kaurane diterpenoid; isolation.

Publication types

Review

Grants and funding

This study forms part of an ongoing study funded by the National Natural Science Foundation of China (Research Fund for Young International Scientists, No: 82150410450).