Increased intestinal permeability in atopic eczema

J Invest Dermatol. 1986 Feb;86(2):101-4. doi: 10.1111/1523-1747.ep12284035.


We have investigated gastrointestinal permeability in children with atopic eczema by measuring the relative urinary excretion rates of the inert di- and monosaccharides lactulose and rhamnose following their oral administration. The median lactulose/rhamnose ratio was greater in 26 children with atopic eczema than in a control group of 29 children which included both healthy individuals and others with various noneczematous dermatoses. This increased permeability may be a primary abnormality of the gut or may reflect intestinal mucosal damage caused by local hypersensitivity reactions to food antigens.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Dermatitis, Atopic / metabolism*
  • Female
  • Food Hypersensitivity / complications
  • Gastrointestinal Diseases / etiology
  • Humans
  • Infant
  • Intestinal Mucosa / metabolism*
  • Lactulose / metabolism
  • Male
  • Permeability
  • Rhamnose / metabolism


  • Lactulose
  • Rhamnose