What clinic closure reveals about care for drug-resistant TB: a qualitative study

BMC Infect Dis. 2023 Jul 17;23(1):474. doi: 10.1186/s12879-023-08405-7.

Abstract

Background: There have been calls for "person-centered" approaches to drug-resistant tuberculosis (DR-TB) care. In 2020, Charles James Hospital in South Africa, which incorporated person-centered care, was closed. Patients were referred mid-course to a centralized, tertiary hospital, providing an opportunity to examine person-centered DR-TB and HIV care from the perspective of patients who lost access to it.

Methods: The impact of transfer was explored through qualitative interviews performed using standard methods. Analysis involved grounded theory; interviews were assessed for theme and content.

Results: After switching to the centralized site, patients reported being unsatisfied with losing access to a single clinic and pharmacy where DR-TB, HIV and chronic disease care were integrated. Patients also reported a loss of care continuity; at the decentralized site there was a single, familiar clinician whereas the centralized site had multiple, changing clinicians and less satisfactory communication. Additionally, patients reported more disease-related stigma and less respectful treatment, noting the loss of a "special place" for DR-TB treatment.

Conclusion: By focusing on a DR-TB clinic closure, we uncovered aspects of person-centered care that were critical to people living with DR-TB and HIV. These perspectives can inform how care for DR-TB is operationalized to optimize treatment retention and effectiveness.

Keywords: Drug-resistant tuberculosis; Multidrug-resistant tuberculosis; Patient-centered care; Qualitative research; Rifampin-resistant tuberculosis.

MeSH terms

  • Antitubercular Agents / therapeutic use
  • HIV Infections* / drug therapy
  • Hospitals
  • Humans
  • Qualitative Research
  • South Africa
  • Tuberculosis, Multidrug-Resistant* / drug therapy

Substances

  • Antitubercular Agents