Obesity negatively impacts maintenance of antibody response to COVID-19 vaccines

Camille Chauvin; Sruthi Vijaya Retnakumar; Jagadeesh Bayry

doi:10.1016/j.xcrm.2023.101117

Obesity negatively impacts maintenance of antibody response to COVID-19 vaccines

Cell Rep Med. 2023 Jul 18;4(7):101117. doi: 10.1016/j.xcrm.2023.101117.

Authors

Camille Chauvin¹, Sruthi Vijaya Retnakumar¹, Jagadeesh Bayry²

Affiliations

¹ Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, 75006 Paris, France.
² Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, 75006 Paris, France; Department of Biological Sciences & Engineering, Indian Institute of Technology Palakkad, Palakkad 678623, India. Electronic address: bayry@iitpkd.ac.in.

Abstract

Severe obesity accelerates the decline of neutralizing antibodies to COVID-19 vaccines contributing to increased risk of hospitalization from breakthrough SARS-CoV-2 infections.¹ These findings have repercussion on the vaccination policy for SARS-CoV-2 variants and other infectious diseases like influenza in obese population.

MeSH terms

Antibody Formation
COVID-19 Vaccines* / administration & dosage
COVID-19* / prevention & control
Humans
Obesity*
SARS-CoV-2

Substances

COVID-19 Vaccines

Supplementary concepts

SARS-CoV-2 variants