The exposure to either medical sources or accidental radiation can cause varying degrees of radiation injury (RI). RI is a common disease involving multiple human body parts and organs, yet effective treatments are currently limited. Accumulating evidence suggests gut microbiota are closely associated with the development and prevention of various RI. This article summarizes 10 common types of RI and their possible mechanisms. It also highlights the changes and potential microbiota-based treatments for RI, including probiotics, metabolites, and microbiota transplantation. Additionally, a 5P-Framework is proposed to provide a comprehensive strategy for managing RI.
Keywords: fecal microbiota transplant; ionizing radiation; microbiome; microbiota medicine; nuclear; radiation-induced injury; short-chain fatty acids; war; washed microbiota transplantation.
© The Author(s) 2023. Published by Oxford University Press on behalf of Higher Education Press.