Irritable bowel syndrome: Epidemiology, overlap disorders, pathophysiology and treatment

World J Gastroenterol. 2023 Jul 14;29(26):4120-4135. doi: 10.3748/wjg.v29.i26.4120.


Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disease with a significant impact on patients' quality of life and a high socioeconomic burden. And the understanding of IBS has changed since the release of the Rome IV diagnosis in 2016. With the upcoming Rome V revision, it is necessary to review the results of IBS research in recent years. In this review of IBS, we can highlight future concerns by reviewing the results of IBS research on epidemiology, overlap disorders, pathophysiology, and treatment over the past decade and summarizing the latest research.

Keywords: Irritable bowel syndrome; Overlap; Pathophysiology; Treatment.

Publication types

  • Review

MeSH terms

  • Humans
  • Irritable Bowel Syndrome* / diagnosis
  • Irritable Bowel Syndrome* / epidemiology
  • Irritable Bowel Syndrome* / therapy
  • Prevalence
  • Quality of Life
  • Severity of Illness Index