Skin permeability of various non-steroidal anti-inflammatory drugs in man

Life Sci. 1986 Sep 22;39(12):1043-50. doi: 10.1016/0024-3205(86)90195-5.

Abstract

The skin permeabilities of a series of eight salicylates and ten non-steroidal anti-inflammatory drugs were investigated in human subjects. The logarithms of % absorption through intact skin and of n-octanol/water partition coefficients (log P) of the test compounds were plotted against one another, and a parabolic relationship was obtained in both compound series.

MeSH terms

  • Absorption
  • Administration, Topical
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / metabolism*
  • Humans
  • Kinetics
  • Salicylates / administration & dosage
  • Salicylates / metabolism
  • Skin / metabolism*

Substances

  • Anti-Inflammatory Agents
  • Salicylates