Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases?

Aging (Albany NY). 2023 Jul 20;15(14):6632-6640. doi: 10.18632/aging.204920. Epub 2023 Jul 20.

Abstract

Both individuals taking rapamycin, an anti-aging drug, and those not taking it will ultimately succumb to age-related diseases. However, the former, if administered disease-oriented dosages for a long time, may experience a delayed onset of such diseases and live longer. The goal is to delay a particular disease that is expected to be life-limiting in a particular person. Age-related diseases, quasi-programmed during development, progress at varying rates in different individuals. Rapamycin is a prophylactic anti-aging drug that decelerates early development of age-related diseases. I further discuss hyperfunction theory of quasi-programmed diseases, which challenges the need for the traditional concept of aging itself.

Keywords: Alzheimer’s disease; cancer; health span; hyperfunction; lifespan; mTOR.

MeSH terms

  • Aging
  • Humans
  • Longevity*
  • Sirolimus* / pharmacology

Substances

  • Sirolimus