Catalytic spike antibodies: A new paradigm in neutralization

Cell Chem Biol. 2023 Jul 20;30(7):701-702. doi: 10.1016/j.chembiol.2023.06.025.

Abstract

In this issue, McConnell et al.10 demonstrate that COVID-19 convalescent plasma (CCP)-derived antibodies can neutralize SARS-CoV-2 by proteolytically cleaving the spike protein. The CCP antibody-mediated catalysis has broader implications beyond COVID-19 and can be applicable in understanding the mechanism of antibody-based neutralization of different pathogens.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Antibodies
  • Antibodies, Catalytic*
  • Antibodies, Neutralizing
  • COVID-19 Serotherapy
  • COVID-19*
  • Humans
  • SARS-CoV-2

Substances

  • Antibodies, Catalytic
  • Antibodies
  • Antibodies, Neutralizing