Treatment of osteoporosis with denosumab in patients with decreased kidney function

Arch Osteoporos. 2023 Jul 26;18(1):104. doi: 10.1007/s11657-023-01306-x.

Abstract

Introduction: Little is known about treatment of osteoporosis with denosumab (Prolia®) in patients with decreased kidney function. The aim of this retrospective case report study was to investigate effects and side-effects of such treatment.

Methods: Since 2012, 75 patients with osteoporosis and decreased kidney function had been treated with denosumab (Prolia®) in the osteoporosis outpatient clinic of the department of endocrinology, Bispebjerg Hospital, University of Copenhagen, Denmark, and data were retrospectively collected from the patient records of these patients in 2021.

Results: At baseline, the mean estimated glomerular filtration rate (eGFR) was 34 mL/min (range 9-50) and the median age was 85 years (range 45-103). 95% of the patients had had low-energy fractures, and the bone mineral density T score of the hips was on average - 2.7. All, but one, patients had normal/high parathyroid hormone (PTH) levels. The mean duration of the treatment with denosumab at the follow-up was 5.3 years (range 1.5-10). There was an annual increase of 12% and of 7% in the T score of in the lumbar spine and hip, respectively, compared to the T-scores prior to the denosumab treatment. 20% had a new fracture during the follow-up. 21% had biochemical hypocalcemia following denosumab injection, 7% developed symptoms of hypocalcemia, whereas 4% needed to be hospitalized acutely.

Conclusion: Treatment with denosumab of osteoporosis in patients with decreased kidney function (eGFR 9-50 mL/min), with normal/high PTH, seems in general to be well tolerated, with improvement of bone and decreased risk of new fractures.

Keywords: Chronic kidney disease; Decreased kidney function; Denosumab; Fractures; Osteoporosis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Bone Density
  • Bone Density Conservation Agents* / adverse effects
  • Denosumab / adverse effects
  • Humans
  • Hypocalcemia* / chemically induced
  • Hypocalcemia* / complications
  • Hypocalcemia* / drug therapy
  • Kidney
  • Middle Aged
  • Osteoporosis* / etiology
  • Osteoporotic Fractures* / drug therapy
  • Osteoporotic Fractures* / prevention & control
  • Retrospective Studies

Substances

  • Denosumab
  • Bone Density Conservation Agents