Ovarian Clear Cell Carcinoma: Genomic Characterization, Pathogenesis and Targeted Therapy

Anticancer Res. 2023 Aug;43(8):3401-3410. doi: 10.21873/anticanres.16515.


Ovarian clear cell carcinomas (OCCCs) are a subtype of ovarian epithelial tumors that arise from the malignant transformation of endometriosis (EMs). These tumors have distinctive molecular features, high malignant potential, low sensitivity to conventional chemotherapy, and poor prognosis. The process and mechanism of malignant transformation from EMs to OCCCs remains elusive. Elucidation of the molecular pathogenesis and drug resistance mechanism of OCCCs is essential to guide the clinical management and basic research of this disease. This paper provides a comprehensive review of the mechanisms of malignant transformation, genomic characteristics, drug resistance and targeted therapy of OCCCs. The review aims to provide new insights for the clinical management of advanced OCCCs.

Keywords: Endometriosis; endometriosis-associated ovarian cancer; ovarian clear cell carcinoma; oxidative stress; review.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma, Clear Cell* / genetics
  • Adenocarcinoma, Clear Cell* / pathology
  • Adenocarcinoma, Clear Cell* / therapy
  • Carcinoma, Ovarian Epithelial
  • Endometriosis* / drug therapy
  • Endometriosis* / genetics
  • Female
  • Genomics
  • Humans
  • Ovarian Neoplasms* / drug therapy
  • Ovarian Neoplasms* / genetics