STK4 deficiency and epidermodysplasia verruciformis-like lesions: A case report

Pediatr Dermatol. 2024 Jan-Feb;41(1):96-99. doi: 10.1111/pde.15400. Epub 2023 Jul 29.

Abstract

Serine/threonine kinase 4 deficiency (STK4 or MST1, OMIM:614868) is an autosomal recessive (AR) combined immunodeficiency that can present with skin lesions such as epidermodysplasia verruciformis-like lesions (EVLL). Herein, we describe a 17-year-old male patient born from consanguineous parents presenting with recurrent respiratory infections, verruciform plaques, poikiloderma, chronic benign lymphoproliferation, and Sjögren syndrome with suspected interstitial lymphocytic pneumonia.

Keywords: STK4 protein; epidermodysplasia verruciformis; primary immunodeficiency diseases.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Epidermodysplasia Verruciformis* / diagnosis
  • Epidermodysplasia Verruciformis* / genetics
  • Epidermodysplasia Verruciformis* / pathology
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Male
  • Papillomaviridae
  • Primary Immunodeficiency Diseases* / diagnosis
  • Protein Serine-Threonine Kinases
  • Skin Diseases*

Substances

  • STK4 protein, human
  • Protein Serine-Threonine Kinases
  • Intracellular Signaling Peptides and Proteins