Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Jun;18(3-4):407-12.
doi: 10.1007/BF01965005.

Pharmacology of an Extract of Salai Guggal ex-Boswellia Serrata, a New Non-Steroidal Anti-Inflammatory Agent

Pharmacology of an Extract of Salai Guggal ex-Boswellia Serrata, a New Non-Steroidal Anti-Inflammatory Agent

G B Singh et al. Agents Actions. .

Abstract

Pharmacological evaluation of alcoholic extract of salai guggal (AESG) has been carried out in experimental animals. AESG displayed marked anti-inflammatory activity in carrageenan induced oedema in rats and mice and dextran oedema in rats. It was equally effective in adrenalectomised rats. In formaldehyde and adjuvant arthritis, AESG produced prominent anti-arthritic activity but no significant effect was observed in cotton pellet-induced granuloma test. It inhibited inflammation induced increase in serum transaminase levels and leucocyte counts but lacked any analgesic or anti-pyretic effects. The gestation period or parturition time in pregnant rats or onset time of castor oil-induced diarrhoea was unaffected by AESG and no significant effect was seen on cardiovascular, respiratory and central nervous system functions. No ulcerogenic effects were found in the rat stomach. The oral and intraperitoneal LD50 was greater than 2 g/Kg in mice and rats.

Similar articles

See all similar articles

Cited by 25 articles

See all "Cited by" articles

References

    1. Planta Med. 1971 Apr;19(4):333-41 - PubMed
    1. J Am Pharm Assoc Am Pharm Assoc. 1957 Sep;46(9):515-9 - PubMed
    1. Nature. 1972 Nov 3;240(5375):21-5 - PubMed
    1. Br J Pharmacol Chemother. 1963 Aug;21:127-36 - PubMed
    1. Prostaglandins. 1974 Jun 25;6(6):523-32 - PubMed

LinkOut - more resources

Feedback