Lorazepam in the treatment of refractory neonatal seizures. A pilot study

Am J Dis Child. 1986 Oct;140(10):1042-4. doi: 10.1001/archpedi.1986.02140240088032.


Seven neonatal patients with severe seizures unresponsive to conventional anticonvulsant therapy were treated with lorazepam. Immediate cessation of seizure activity occurred in all patients within five minutes. Although seizures recurred in two infants eight hours later, frequency and severity diminished. There were no apparent significant side effects attributed to the medication.

MeSH terms

  • Electroencephalography
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Premature, Diseases / drug therapy
  • Infant, Premature, Diseases / physiopathology
  • Lorazepam / therapeutic use*
  • Male
  • Pilot Projects
  • Recurrence
  • Seizures / drug therapy*
  • Seizures / physiopathology


  • Lorazepam