Endocrine disorders associated with obesity

Best Pract Res Clin Obstet Gynaecol. 2023 Aug:90:102394. doi: 10.1016/j.bpobgyn.2023.102394. Epub 2023 Jul 20.

Abstract

Several endocrine disorders, including diabetes, insulinoma, Cushing syndrome, hypothyroidism, polycystic ovarian syndrome, and growth hormone deficiency, are associated with obesity. The mechanisms underlying the development of obesity vary according to the abnormalities of endocrine function. The primary actions of insulin, glucocorticoids (GCs), thyroid hormone, and growth hormone are associated with energy metabolism in the liver, muscle, adipose tissue, and other tissues. This chapter describes the pathogenesis of obesity and metabolic dysfunction associated with excess insulin or GCs and the deficiency of thyroid hormone or growth hormone.

Keywords: Cushing syndrome; Growth hormone deficiency; Hyperinsulinism; Hypothyroidism; Obesity; Type 2 diabetes.

Publication types

  • Review

MeSH terms

  • Female
  • Glucocorticoids / therapeutic use
  • Growth Hormone
  • Humans
  • Insulin Resistance*
  • Insulins*
  • Obesity / complications
  • Polycystic Ovary Syndrome* / complications
  • Thyroid Hormones

Substances

  • Glucocorticoids
  • Thyroid Hormones
  • Growth Hormone
  • Insulins