Neonatal complicated intraabdominal infection

Jessica L Rauh; Alison J Lehane; Leah M Sieren; Lucas P Neff

doi:10.1097/QCO.0000000000000950

Neonatal complicated intraabdominal infection

Curr Opin Infect Dis. 2023 Oct 1;36(5):414-419. doi: 10.1097/QCO.0000000000000950. Epub 2023 Jul 28.

Authors

Jessica L Rauh¹, Alison J Lehane¹, Leah M Sieren², Lucas P Neff²

Affiliations

¹ Wake Forest School of Medicine, General Surgery.
² Wake Forest School of Medicine, General Surgery, Section of Pediatric Surgery, Winston Salem, North Carolina, USA.

PMID: 37527001
DOI: 10.1097/QCO.0000000000000950

Abstract

Purpose of review: The purpose of this review is to summarize the treatment of complicated intraabdominal infections (cIAIs) in premature infants.

Recent findings: Recent work has continued to define the complex nature of cIAIs and necrotizing enterocolitis (NEC). This includes new findings on the microbiome, breast milk and risk factors associated with NEC. The treatment of cIAIs employs a combination of both surgical and medical treatment. Further look at what type and timing of surgical intervention is used as well as the ideal antibiotic regimen. Upcoming research is highlighted in future directions of NEC treatment.

Summary: cIAIs in premature infants is a challenging disease with more research needed to further delineate the pathophysiology and treatment options.

Publication types

Review

MeSH terms

Enterocolitis, Necrotizing* / diagnosis
Enterocolitis, Necrotizing* / epidemiology
Enterocolitis, Necrotizing* / therapy
Female
Humans
Infant
Infant, Newborn
Infant, Premature
Intraabdominal Infections* / drug therapy
Microbiota*
Milk, Human