A Clinical Study of Histopathological and Clinical Image Changes After Sclerotherapy of Lip Venous Malformations

J Craniofac Surg. 2023 Nov-Dec;34(8):2410-2412. doi: 10.1097/SCS.0000000000009563. Epub 2023 Aug 3.


Venous malformations (VMs) are histopathologically benign but can greatly impair patients' quality of life. Screlothprapy is known to be effective in improving symptoms without a scar, but surgical resection of residual lesions is sometimes necessary due to inadequate reduction. However, there is no consensus on what criteria should be used to consider switching to surgical treatment, and individualized decisions must be made for each case. To investigate the factors that contribute to the lack of efficacy of sclerotherapy in reducing lesions and how to predict this, the authors performed a retrospective clinical imaging and histopathological study of 6 cases of labial vein malformations treated with sclerotherapy and 3 cases without sclerotherapy. Clinical image investigations are based on magnetic resonance imaging before and after sclerotherapy. The authors found a significant decrease in the percentage of cystic components in the total lesion of VMs after sclerotherapy. Histopathological investigations are based on resected VMs with or without sclerotherapy. Elastica van Gieson stains suggested a significant increase in fibrotic tissue inside VMs treated with sclerotherapy compared with those without. In conclusion, magnetic resonance imaging signal changes inside the VMs after sclerotherapy was observed, and it may reflect fibrosis of the tissue. These changes in the VMs after sclerotherapy may reduce the effect of sclerotherapy on tissue reduction should be considered.

MeSH terms

  • Humans
  • Lip
  • Magnetic Resonance Imaging
  • Quality of Life
  • Retrospective Studies
  • Sclerosing Solutions / therapeutic use
  • Sclerotherapy* / methods
  • Treatment Outcome
  • Vascular Malformations* / diagnostic imaging
  • Vascular Malformations* / therapy


  • Sclerosing Solutions