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Comment
. 2023 Aug 2;111(15):2277-2279.
doi: 10.1016/j.neuron.2023.06.014.

Timing matters: A protective role of astrocyte reactivity in neurodegeneration

Daniela Rojo  1 , Erin M Gibson  2
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Comment

Timing matters: A protective role of astrocyte reactivity in neurodegeneration

Daniela Rojo et al. Neuron. .
Free article

Abstract

Sheehan and Nadarajah et al.1 identified that Bmal1 loss from astrocytes induces the expression of BAG3, a macroautophagy chaperone enriched in Alzheimer's disease patients and in disease-associated astrocytes, enhancing the phagocytosis of misfolded proteins and preventing tau and alpha-synuclein pathologies.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology.
    Sheehan PW, Nadarajah CJ, Kanan MF, Patterson JN, Novotny B, Lawrence JH, King MW, Brase L, Inman CE, Yuede CM, Lee J, Patel TK, Harari O, Benitez BA, Davis AA, Musiek ES. Sheehan PW, et al. Neuron. 2023 Aug 2;111(15):2383-2398.e7. doi: 10.1016/j.neuron.2023.05.006. Epub 2023 Jun 13. Neuron. 2023. PMID: 37315555 Free PMC article.

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