In situ generation of bioadhesives using dry tannic silk particles: a wet-adhesion strategy relying on removal of hydraulic layer over wet tissues for wound care

Jinyang Luo; Junsu Wang; Qing Li; Li Xiong; Ruiqi Xie; Guangqian Lan; Liang-Ju Ning; Jing Xie; Enling Hu; Bitao Lu

doi:10.1016/j.ijbiomac.2023.126087

In situ generation of bioadhesives using dry tannic silk particles: a wet-adhesion strategy relying on removal of hydraulic layer over wet tissues for wound care

Int J Biol Macromol. 2023 Oct 1:250:126087. doi: 10.1016/j.ijbiomac.2023.126087. Epub 2023 Aug 1.

Authors

Jinyang Luo¹, Junsu Wang², Qing Li¹, Li Xiong¹, Ruiqi Xie¹, Guangqian Lan¹, Liang-Ju Ning³, Jing Xie⁴, Enling Hu⁵, Bitao Lu⁶

Affiliations

¹ State Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China.
² Chongqing Customs Technology Center, Chongqing 400044, China.
³ Department of Orthopedic Surgery and Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China.
⁴ Department of Stomatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
⁵ State Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China; School of Fashion and Textiles, The Hong Kong Polytechnic University, Hong Kong.
⁶ State Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China. Electronic address: lubitao000@email.swu.edu.cn.

PMID: 37536416
DOI: 10.1016/j.ijbiomac.2023.126087

Abstract

Tissue adhesives have been widely used in biomedical applications. However, the presence of a hydrated layer on the surface of wet tissue severely hinders their adhesion capacities, resulting in ineffective wound treatment. To address this issue, a dry particle dressing (plas@SF/tann-hydro-pwd) capable of removing the hydrated layer and converting in situ to bioadhesives (plas@SF/tann-hydro-gel) was fabricated via simple physical mixing based on the hydrophobic-hydrogen bonding synergistic effect and Schiff-base reaction. It was found that the plas@SF/tann-hydro-gel bioadhesive, which was changed from plas@SF/tann-hydro-pwd dressing by adsorption of water, exhibited good wet adhesion to diverse biological tissues. In addition, the wet adhesion qualities of the plas@SF/tann-hydro-gel adhesive was studied under a variety of demanding conditions, including a wide range of temperatures, varying pH levels, highly concentrated salt solutions, and simulated fluids. Experiments on animals had showed that the adhesive plas@SF/tann-hydro-gel has superior wet adhesion qualities and superior wound healing properties compared to the commercial product Tegaderm™. This study develops a new wet-adhesion technique employing dry particle dressing to eliminate the hydrated layer over wet tissues for the in situ creation of gel bioadhesives for wound healing.

Keywords: Dry particle dressing; Wet adhesive; Wound healing.