Unusual locations of localized myxedema in Graves' disease. Report of three cases

Arch Dermatol. 1986 Jan;122(1):85-8.


Three patients with Graves' disease had very unusual locations of localized myxedema. One patient had localized myxedema on the pretibial and shoulder areas after sodium iodide I 131 therapy. The second patient had localized myxedema on his neck, shoulders, and upper part of the back as well as on the pretibial area. The third patient had localized myxedema on the pinnae, also following sodium iodide I 131 therapy. After surgical removal followed by intralesional triamcinolone acetonide injections, the first patient's lesions recurred. The lesions in the second case did not respond to topical steroid cream. The third patient had a partial response to intralesional steroid injections.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Back
  • Ear, External / pathology
  • Female
  • Graves Disease / pathology*
  • Graves Disease / therapy
  • Humans
  • Iodine Radioisotopes / therapeutic use
  • Leg Dermatoses / pathology
  • Leg Dermatoses / therapy
  • Male
  • Middle Aged
  • Myxedema / pathology*
  • Myxedema / surgery
  • Myxedema / therapy
  • Neck / pathology
  • Shoulder / pathology
  • Shoulder / surgery
  • Triamcinolone Acetonide / therapeutic use


  • Iodine Radioisotopes
  • Triamcinolone Acetonide