Application of super-resolution microscopy in mitochondria-dynamic diseases

Adv Drug Deliv Rev. 2023 Sep:200:115043. doi: 10.1016/j.addr.2023.115043. Epub 2023 Aug 1.


Limited by spatial and temporal resolution, traditional optical microscopy cannot image the delicate ultra-structure organelles and sub-organelles. The emergence of super-resolution microscopy makes it possible. In this review, we focus on mitochondria. We summarize the process of mitochondrial dynamics, the primary proteins that regulate mitochondrial morphology, the diseases related to mitochondrial dynamics. The purpose is to apply super-resolution microscopy developed during recent years to the mitochondrial research. By providing the right research tools, we will help to promote the application of this technique to the in-depth elucidation of the pathogenesis of diseases related to mitochondrial dynamics, assistdiagnosis and develop the therapeutic treatment.

Keywords: Disease; Dynamics; Mitochondria; Sub-organelle structures; Super-resolution microscopy.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Microscopy* / methods
  • Mitochondria* / metabolism
  • Organelles