Human Milk Fortification Strategies in the Neonatal Intensive Care Unit

Ting Ting Fu; Brenda B Poindexter

doi:10.1016/j.clp.2023.04.006

Human Milk Fortification Strategies in the Neonatal Intensive Care Unit

Clin Perinatol. 2023 Sep;50(3):643-652. doi: 10.1016/j.clp.2023.04.006. Epub 2023 May 26.

Authors

Ting Ting Fu¹, Brenda B Poindexter²

Affiliations

¹ Division of Neonatology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: tingting.fu@cchmc.org.
² Division of Neonatology, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University School of Medicine, 2015 Uppergate Drive Northeast, Atlanta, GA 30322, USA.

PMID: 37536769
DOI: 10.1016/j.clp.2023.04.006

Abstract

Multicomponent fortification is the standard of care to support short-term growth in preterm infants receiving human milk. There is no consensus regarding the optimal timing, method, or products used to fortify human milk. Both bovine milk-based and human milk-based human milk fortifiers are safe options, though increased fortification and enrichment may be needed to achieve adequate growth. Additional studies are needed to evaluate newer fortifier products and fortification strategies.

Keywords: Fortification; Growth; Human milk; Macronutrients; Nutrition; Preterm infant.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Enterocolitis, Necrotizing*
Food, Fortified
Humans
Infant
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight
Intensive Care Units, Neonatal
Milk, Human*