Actinopyrones A, B and C, new physiologically active substances. I. Producing organism, fermentation, isolation and biological properties

K Yano; K Yokoi; J Sato; J Oono; T Kouda; Y Ogawa; T Nakashima

doi:10.7164/antibiotics.39.32

Actinopyrones A, B and C, new physiologically active substances. I. Producing organism, fermentation, isolation and biological properties

J Antibiot (Tokyo). 1986 Jan;39(1):32-7. doi: 10.7164/antibiotics.39.32.

Authors

K Yano, K Yokoi, J Sato, J Oono, T Kouda, Y Ogawa, T Nakashima

PMID: 3753969
DOI: 10.7164/antibiotics.39.32

Abstract

A strain of Streptomyces was found to produce new physiologically active substances. The active compounds were purified and separated into three substances named actinopyrones A, B and C. Actinopyrones exhibited coronary vasodilating activities in anesthetized dogs and weakly antimicrobial activities against some Gram-positive bacteria and dermatophytes.

MeSH terms

Animals
Blood Pressure / drug effects
Coronary Circulation / drug effects
Dogs
Dose-Response Relationship, Drug
Fermentation
Heart Rate / drug effects
Male
Microbial Sensitivity Tests
Pyrans / isolation & purification*
Pyrones / isolation & purification*
Pyrones / pharmacology
Regional Blood Flow / drug effects
Streptomyces / analysis*
Streptomyces / classification

Substances

Pyrans
Pyrones
actinopyrone A
actinopyrone B
actinopyrone C