Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

Nature. 1986 Mar;320(6058):134-9. doi: 10.1038/320134a0.


We have cloned and sequenced the complete complementary DNA of the oestrogen receptor (ER) present in the breast cancer cell line MCF-7. The expression of the ER cDNA in HeLa cells produces a protein that has the same relative molecular mass and binds oestradiol with the same affinity as the MCF-7 ER. There is extensive homology between the ER and the erb-A protein of the oncogenic avian erythroblastosis virus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cloning, Molecular
  • DNA / genetics
  • Female
  • Gene Expression Regulation
  • HeLa Cells
  • Humans
  • Oncogenes*
  • Protein Conformation
  • RNA Caps
  • Receptors, Estrogen / genetics*
  • Sequence Homology, Nucleic Acid
  • Solubility


  • RNA Caps
  • Receptors, Estrogen
  • DNA

Associated data

  • GENBANK/M11457