Hafnium carbide nanoparticles for noninflammatory photothermal cancer therapy

Yan Ma; Haitao Wu; Qinglong Guo; Xingliang Dai; Peisan Wang; Wei Zhang; Dongdong Liu; Xulin Chen; Haisheng Qian; Xianwen Wang

doi:10.1016/j.jcis.2023.07.165

Hafnium carbide nanoparticles for noninflammatory photothermal cancer therapy

J Colloid Interface Sci. 2023 Dec:651:47-58. doi: 10.1016/j.jcis.2023.07.165. Epub 2023 Jul 27.

Authors

Yan Ma¹, Haitao Wu², Qinglong Guo³, Xingliang Dai³, Peisan Wang², Wei Zhang², Dongdong Liu³, Xulin Chen⁴, Haisheng Qian⁵, Xianwen Wang⁶

Affiliations

¹ College and Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei 230032, China; School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032, China.
² School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032, China.
³ Department of Neurosurgery, the First Affiliated Hospital of Anhui Medical University, Hefei 230032, China.
⁴ Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China.
⁵ College and Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei 230032, China.
⁶ College and Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei 230032, China; School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032, China. Electronic address: xianwenwang@ahmu.edu.cn.

PMID: 37540929
DOI: 10.1016/j.jcis.2023.07.165

Abstract

Photothermal therapy (PTT) effectively suppresses tumor growth with high selectivity. Nevertheless, PTT may cause an inflammatory response that leads to tumor recurrence and treatment resistance, which are the main disadvantages of PTT. Herein, monodisperse hafnium carbide nanoparticles (HfC NPs) were successfully prepared for noninflammatory PTT of cancer. HfC NPs possessed satisfactory near-infrared (NIR) absorption, good photothermal conversion efficiency (PTCE, 36.8 %) and photothermal stability. Furthermore, holding large surface areas and intrinsic redox-active sites, HfC NPs exhibited excellent anti-inflammatory properties due to their antioxidant and superoxide dismutase (SOD) enzymatic activities. In vitro and in vivo experiments confirmed that HfC NPs converted light energy into heat energy upon NIR laser irradiation to kill cancer cells through PTT and achieved a better therapeutic effect by anti-inflammatory effects after PTT. This work highlights that multifunctional HfC NPs can be applied in noninflammatory PTT with outstanding safety and efficacy.

MeSH terms

Cell Line, Tumor
Hafnium
Humans
Nanoparticles* / chemistry
Neoplasms* / therapy
Phototherapy
Photothermal Therapy

Substances

Hafnium