NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation

Elliott M Bernard; Petr Broz

doi:10.1016/j.molcel.2023.07.005

NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation

Mol Cell. 2023 Aug 3;83(15):2621-2623. doi: 10.1016/j.molcel.2023.07.005.

Authors

Elliott M Bernard¹, Petr Broz²

Affiliations

¹ Department of Immunobiology, University of Lausanne, Lausanne, Switzerland.
² Department of Immunobiology, University of Lausanne, Lausanne, Switzerland. Electronic address: petr.broz@unil.ch.

PMID: 37541218
DOI: 10.1016/j.molcel.2023.07.005

Abstract

Red blood cell rupture (hemolysis) activates innate immunity and inflammation by releasing heme. Sundaram et al.¹ implicate the immune sensor NLRP12 in hemolytic disease, showing that it controls necrotic cell death induction in response to heme combined with pathogen-associated molecules.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cell Death
Heme* / metabolism
Hemolysis
Humans
Immunity, Innate
Inflammation / metabolism
Intracellular Signaling Peptides and Proteins
Necrosis
Pathogen-Associated Molecular Pattern Molecules*

Substances

Heme
Pathogen-Associated Molecular Pattern Molecules
NLRP12 protein, human
Intracellular Signaling Peptides and Proteins