Abstract
Two novel prenylated flavones, termed Cannflavin A and B, were isolated from the cannabinoid free ethanolic extract of Cannabis sativa L. Both compounds inhibited prostaglandin E2 production by human rheumatoid synovial cells in culture.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Arthritis, Rheumatoid / metabolism
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Cannabis / analysis*
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Flavones
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Humans
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Plant Extracts / isolation & purification*
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Plant Extracts / pharmacology
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Prostaglandin Antagonists / isolation & purification*
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Prostaglandins E / biosynthesis
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Structure-Activity Relationship
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Synovial Fluid / drug effects
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Synovial Fluid / metabolism
Substances
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Flavones
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Plant Extracts
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Prostaglandin Antagonists
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Prostaglandins E
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cannflavin