Neuropeptide substance P: A promising regulator of wound healing in diabetic foot ulcers

Biochem Pharmacol. 2023 Sep:215:115736. doi: 10.1016/j.bcp.2023.115736. Epub 2023 Aug 5.


In the past, neuropeptide substance P (SP) was predominantly recognized as a neuroinflammatory factor, while its potent healing activity was overlooked. This paper aims to review the regulatory characteristics of neuropeptide SP in both normal and diabetic wound healing. SP actively in the regulation of wound healing-related cells directly and indirectly, exhibiting robust inflammatory properties, promoting cell proliferation and migration and restoring the activity and paracrine ability of skin cells under diabetic conditions. Furthermore, SP not only regulates healing-related cells but also orchestrates the immune environment, thereby presenting unique and promising application prospects in wound intervention. As new SP-based preparations are being explored, SP-related drugs are poised to become an effective therapeutic intervention for diabetic foot ulcers (DFU).

Keywords: Angiogenesis; Diabetic foot ulcers; Fibroblasts; Stem cell therapy; Substance P; Wound healing.

Publication types

  • Review

MeSH terms

  • Cell Proliferation
  • Diabetes Mellitus*
  • Diabetic Foot* / drug therapy
  • Humans
  • Skin
  • Substance P / pharmacology
  • Substance P / therapeutic use
  • Wound Healing


  • Substance P