Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the prohormone sequence

FEBS Lett. 1986 Jul 14;203(1):25-30. doi: 10.1016/0014-5793(86)81429-6.

Abstract

A cDNA clone encoding guinea pig preproglucagon has been isolated from a pancreatic cDNA library. The predicted amino acid sequence of proglucagon is highly conserved in all regions, in comparison to other mammals, except for the C-terminal portion of the 29-residue glucagon region, in which 5 amino acid substitutions have occurred. These changes may serve to offset the reduced receptor-binding potency of the highly mutated insulin in this New World species.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA / genetics
  • Glucagon / genetics*
  • Guinea Pigs
  • Mutation
  • Proglucagon
  • Protein Precursors / genetics*
  • Sequence Homology, Nucleic Acid

Substances

  • Protein Precursors
  • Proglucagon
  • DNA
  • Glucagon

Associated data

  • GENBANK/X04071