The authors present three recent cases of intraocular lymphoma. All three patients presented with apparent hypopyon and uveitis. Although the diagnosis was a difficult one to make, an aspiration of the anterior chamber with appropriate cytologic studies was conclusive in one case. The neoplasm may masquerade as any type of intraocular inflammation, anterior or posterior. We discuss the management and prognosis of these patients and review 68 cases from the world literature. Radiation therapy plays an important palliative role in this condition.