The Role of MRI in Differentiating Demyelinating and Inflammatory (not Infectious) Myelopathies

Semin Ultrasound CT MR. 2023 Oct;44(5):469-488. doi: 10.1053/j.sult.2023.03.017. Epub 2023 Apr 5.


Demyelinating and inflammatory myelopathies represent a group of diseases with characteristic patterns in neuroimaging and several differential diagnoses. The main imaging patterns of demyelinating myelopathies (multiple sclerosis, neuromyelitis optica spectrum disorder, acute disseminated encephalomyelitis, and myelin oligodendrocyte glycoprotein antibody-related disorder) and inflammatory myelopathies (systemic lupus erythematosus-myelitis, sarcoidosis-myelitis, Sjögren-myelitis, and Behçet's-myelitis) will be discussed in this article, highlighting key points to the differential diagnosis.

Publication types

  • Review

MeSH terms

  • Humans
  • Magnetic Resonance Imaging
  • Multiple Sclerosis* / diagnostic imaging
  • Myelitis* / diagnosis
  • Neuromyelitis Optica* / diagnostic imaging
  • Spinal Cord Diseases*