Pre-discharge 18F-Flourodeoxyglucose uptake pattern following transcatheter aortic-valve replacement and adverse prognostic features in aortic stenosis

Abstract

¹⁸F-Flourodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG-PET/CT) has been shown to be of utility in transcatheter aortic valve replacement (TAVR) patients with suspected prosthetic valve endocarditis. In the present study, we sought to analyze the relationship between ¹⁸F-FDG-PET/CT performed before discharge in TAVR patients and adverse prognostic features of aortic stenosis. We analyzed the association between ¹⁸F-FDG-PET/CT uptake pattern and degree of left ventricular mass index, aortic root dilatation, and aortic leaflet calcification extent. This is the first study to demonstrate that pre-discharge ¹⁸F-FDG-PET/CT in patients undergoing TAVR shows a significant negative correlation between ¹⁸F-FDG uptake pattern and adverse prognostic features.

Keywords: 18F-flourodeoxyglucose; Aortic stenosis; Aortic valve replacement.