Bronchiolocentric chronic lymphocytic leukemia

Cancer. 1986 Oct 15;58(8):1695-8. doi: 10.1002/1097-0142(19861015)58:8<1695::aid-cncr2820580819>;2-y.


Three patients presented with symptoms of severe dyspnea, radiologic evidence of bilateral pulmonary infiltrates, and one had diffuse wheezing on auscultation. Open-lung biopsies revealed a neoplastic lymphocytic infiltrate in an exquisitely bronchiolocentric distribution with relative sparing of the rest of the lung parenchyma. Two patients had a history of chronic lymphocytic leukemia (CLL), whereas pulmonary disease was the initial manifestation of the lymphoproliferative disorder in the third. Clinical and pathologic features of the three cases are discussed.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Bronchi / pathology
  • Bronchial Diseases / drug therapy
  • Bronchial Diseases / etiology
  • Bronchial Diseases / pathology*
  • Female
  • Humans
  • Leukemia, Lymphoid / complications
  • Leukemia, Lymphoid / pathology*
  • Male
  • Middle Aged
  • Steroids / therapeutic use


  • Steroids