The regulation of lncRNAs and miRNAs in SARS-CoV-2 infection

Front Cell Dev Biol. 2023 Jul 27:11:1229393. doi: 10.3389/fcell.2023.1229393. eCollection 2023.


The coronavirus disease 2019 (COVID-19) was a global endemic that continues to cause a large number of severe illnesses and fatalities. There is increasing evidence that non-coding RNAs (ncRNAs) are crucial regulators of viral infection and antiviral immune response and the role of non-coding RNAs in SARS-CoV-2 infection has now become the focus of scholarly inquiry. After SARS-CoV-2 infection, some ncRNAs' expression levels are regulated to indirectly control the expression of antiviral genes and viral gene replication. However, some other ncRNAs are hijacked by SARS-CoV-2 in order to help the virus evade the immune system by suppressing the expression of type I interferon (IFN-1) and controlling cytokine levels. In this review, we summarize the recent findings of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) among non-coding RNAs in SARS-CoV-2 infection and antiviral response, discuss the potential mechanisms of actions, and prospects for the detection, treatment, prevention and future directions of SARS-CoV-2 infection research.

Keywords: COVID-19; SARS-CoV-2; lncRNA; mechanism; miRNA; non-coding RNA.

Publication types

  • Review

Grants and funding

This work was supported by grants from National Natural Science Foundation of China (Grant number 32170939 and 82111530302). Guangdong Basic and Applied Basic Research Foundation (Grant number 2022B1515020075). Shenzhen Science and Technology Innovation Commission for Research and Development Project (Grant number JCYJ20190809183205622). Guangdong Science and Technology Program key projects (No. 2021B1212030014). The Basic Research Project of Key Laboratory of Guangzhou (No. 202102100001).