Hypomagnesemia and renal magnesium wasting in patients receiving cisplatin

Ann Intern Med. 1979 Jun;90(6):929-31. doi: 10.7326/0003-4819-90-6-929.


We studied renal function and serum electrolytes in 51 patients receiving cisplatin chemotherapy by retrospectively reviewing the charts of 44 patients and prospectively following seven patients. Hypomagnesemia developed in 23 of 44 evaluable patients who were receiving cisplatin. We documented inappropriate renal magnesium wasting in four patients. Two patients required hospitalization for symptomatic hypomagnesemia. We conclude that cisplatin can induce a renal tubular defect in magnesium conservation and serious clinical syndromes of magnesium deficiency.

Publication types

  • Clinical Trial

MeSH terms

  • Acute Kidney Injury / chemically induced*
  • Adult
  • Aged
  • Cisplatin / adverse effects*
  • Clinical Trials as Topic
  • Female
  • Humans
  • Kidney Function Tests
  • Kidney Tubular Necrosis, Acute / chemically induced*
  • Kidney Tubules / drug effects*
  • Kidney Tubules / metabolism
  • Magnesium / metabolism*
  • Magnesium Deficiency / chemically induced*
  • Male
  • Middle Aged
  • Neoplasms / drug therapy
  • Prospective Studies
  • Retrospective Studies


  • Magnesium
  • Cisplatin