The road not taken en route to T cell exhaustion

Nat Immunol. 2023 Sep;24(9):1402-1404. doi: 10.1038/s41590-023-01596-w.


The first detailed investigation of CD8+ tumor-infiltrating T cell differentiation in the hours after cells enter a tumor has yielded an unexpected twist. Naive T cells veer away from effector fate and enter the path towards exhaustion much earlier than expected.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • CD8-Positive T-Lymphocytes*
  • T-Cell Exhaustion*