Silicone prosthetics and anti-thyroid autoimmunity

Langenbecks Arch Surg. 2023 Aug 15;408(1):312. doi: 10.1007/s00423-023-03030-z.


Introduction: In esthetic surgery, the use of silicone implants is a topic of hot discussion.

Material and methods: An analysis of 119 esthetic surgical interventions on the mammary gland was performed. A study of the immune and endocrine parameters after mammoplasty was carried out.

Results: The phenomenon of an increase in the levels of autoantibodies to the TSH receptor was revealed. The phenomenon of pre-operative growth of prolactin and TSH levels has been confirmed. An increase in thyroid autoimmunity after silicone mammoplasty is interpreted as a result of a silicone adjuvant action. An increase in the incidence of ASIA syndrome in patients who underwent breast surgery was registered. However, it was observed in both patients with silicone and non-silicone breast surgeries and therefore could not be solely explained by the use of silicone. Within 12 months following silicone mammoplasty, the patients with an increase of anti-TSH receptor autoimmunity nevertheless did not show any clinical and laboratory signs of overt thyroid disease, thus staying in a pre-nosological state. PRACTICAL RECOMMENDATIONS: Based on these results, we recommend the following for esthetic surgery: (a) all patients planned for silicone implant surgery should be examined for autoantibodies to the TSH receptor and (b) patients who have undergone breast endoprosthesis, starting 6 months after the operation, need long-term follow-up for thyroid status with mandatory testing for the level of these autoantibodies.

Keywords: ASIA syndrome; Prolactin; Silicone breast implants; TSH; TSHR-ab.

MeSH terms

  • Autoantibodies
  • Autoimmunity*
  • Breast Implants* / adverse effects
  • Humans
  • Silicones / adverse effects
  • Thyroid Gland


  • Silicones
  • Autoantibodies