Extramitochondrial ATP as [Ca2+]m and cardiolipin content regulator

Biochim Biophys Acta Biomembr. 2023 Dec;1865(8):184213. doi: 10.1016/j.bbamem.2023.184213. Epub 2023 Aug 14.

Abstract

An ATP-induced increase of [Ca2+]m in myometrium mitochondria matrix at the absence of exogenous Ca2+ was shown. An ATP-induced increase of Сa2+ efflux from mitochondria ([Сa2+]o) has also been shown. Mitochondria membranes were polarized upon incubation in both Mg2+- and Mg2+,ATP-medium. Cardiolipin (CL) content in mitochondria membranes decreased upon incubation of organelles in Mg2+,ATP-medium as compared to Mg2+-medium. It was suggested that ATP could play the role of a signaling molecule regulating the Ca2+ exchange in the mitochondria.

Keywords: Ca(2+); Cardiolipin; Mg(2+)ATP; Mitochondria; Myometrium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Cardiolipins* / metabolism
  • Female
  • Humans
  • Mitochondria*
  • Mitochondrial Membranes / metabolism
  • Myometrium / metabolism

Substances

  • Cardiolipins
  • Adenosine Triphosphate