Research progress on the mechanism of renal interstitial fibrosis in obstructive nephropathy

Kangning Wang; Qiuling Liao; Xiang Chen

doi:10.1016/j.heliyon.2023.e18723

Research progress on the mechanism of renal interstitial fibrosis in obstructive nephropathy

Heliyon. 2023 Jul 27;9(8):e18723. doi: 10.1016/j.heliyon.2023.e18723. eCollection 2023 Aug.

Authors

Kangning Wang¹, Qiuling Liao², Xiang Chen¹

Affiliations

¹ Department of Urology Surgery, Xiangya Hospital Central South University, Changsha City, Hunan Province, 410008, China.
² Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha City, Hunan Province, 410011, China.

Abstract

Renal fibrosis is a common result for various chronic kidney diseases developing to the end stage. It is a pathological process characterized by the destruction of normal kidney structure and the subsequent replacement with fibrous tissue, which primarily involves fibroblast proliferation and extracellular matrix deposition. Obstruction is a common cause of renal fibrosis, and obstructive renal fibrosis is a common disease in urology. Obstructive renal fibrosis, characterized by its insidious onset, is the result of a complex interplay of multiple factors. These factors encompass renal tubular epithelial cell injury, the presence of a hypoxic microenvironment in affected kidney tissue, inflammatory cell infiltration, release of inflammatory mediators, and the release of renal fibrosis growth factors, among others. This paper reviews the research progress on the mechanism and treatment of renal interstitial fibrosis.

Keywords: Cell injury; Growth factor; Inflammation; Obstructive nephropathy; Renal interstitial fibrosis.

Publication types

Review