[Local administration of amphotericin B by VAC instillation: Therapeutic aid in the treatment of mucormycosis]

Abstract

Mucormycosis is a rare and serious fungal infection, occurring mainly in immunocompromised, diabetic, polytrauma or burn patients. Current standard treatments include iterative carcinological surgical trimming, systemic treatment with liposomal amphotericin B and second-line Posaconazole or Isavuconazole. We report the case of a 37-year-old female patient with no previous medical history who developed a disseminated mucormycosis, with an estimated 25 % loss of skin substance and major decay of the chest wall. In addition to standard treatment, local instillations of amphotericin B using the VAC Veraflow® system were performed. We believe that local instillations of amphotericin B by VAC could improve the functional prognosis of patients with skin involvement.

Keywords: Adjuvant local treatment; Amphotericin B; Amphotéricine B; Instillation; Mucormycose; Mucormycosis; Negative pressure therapy; Thérapie par pression négative; Traitement local adjuvant.