Circulating hyaluronidase in early pregnancy and increased risk of gestational diabetes in Chinese pregnant women: A nested case control study

Ming Gao; Jing Li; Ninghua Li; Weiqin Li; Shuang Zhang; Tao Zhang; Hui Wang; Zhongze Fang; Zhijie Yu; Gang Hu; Junhong Leng; Xilin Yang

doi:10.1016/j.cca.2023.117512

Circulating hyaluronidase in early pregnancy and increased risk of gestational diabetes in Chinese pregnant women: A nested case control study

Clin Chim Acta. 2023 Aug 1:548:117512. doi: 10.1016/j.cca.2023.117512. Epub 2023 Aug 19.

Authors

Ming Gao¹, Jing Li², Ninghua Li¹, Weiqin Li³, Shuang Zhang³, Tao Zhang³, Hui Wang¹, Zhongze Fang⁴, Zhijie Yu⁵, Gang Hu⁶, Junhong Leng⁷, Xilin Yang⁸

Affiliations

¹ Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
² Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China; Tianjin Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin 300070, China.
³ Project Office, Tianjin Women and Children's Health Center, Tianjin 300070, China.
⁴ Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
⁵ Population Cancer Research Program and Department of Pediatrics, Dalhousie University, 15000 Halifax, Canada.
⁶ Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
⁷ Project Office, Tianjin Women and Children's Health Center, Tianjin 300070, China. Electronic address: ljhlzqljhlzq@163.com.
⁸ Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China; Tianjin Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin 300070, China. Electronic address: yxl@hotmail.com.

PMID: 37598741
DOI: 10.1016/j.cca.2023.117512

Abstract

Background and aims: To explore association of serum hyaluronidase 1 (HYAL1) level in early pregnancy with gestational diabetes mellitus (GDM), and to examine interactive effects of HYAL1 with ceramides species on GDM risk.

Materials and methods: We conducted a 1:1 matched case-control study (n = 414) of pregnant women from 2010 to 2012 in Tianjin, China. Blood samples were collected at the first antenatal care visit (at a median of 10^th gestational weeks). Binary conditional logistic regression and restricted cubic spline (RCS) analysis were used to examine full-range risk association between HYAL1 and GDM. Additive interactions and multiplicative interactions were employed to test interactive effects of HYAL1 with ceramides species on GDM risk.

Results: Ln HYAL1 was linearly associated with GDM risk and the adjusted OR of HYAL1 ≥ vs. < its median for GDM was significant (1.65, 95%CI: 1.08-2.52). High HYAL1 markedly enhanced the ORs of high ceramide 18:0 for GDM from 2.31 (1.06-5.01) to 6.74 (2.85-16.0), and low ceramide 24:0 from 3.08 (1.33-7.11) to 8.15 (3.03-21.9), with significant additive interactions.

Conclusions: High HYAL1 in early pregnancy may increase the risk of GDM in Chinese women, possibly via enhancing the effects of high ceramide 18:0 and low ceramide 24:0 on GDM risk.

Keywords: Additive interaction; Ceramides; Gestational diabetes mellitus; Hyaluronidase 1; Multiplicative interaction.

MeSH terms

Case-Control Studies
Ceramides
Diabetes, Gestational*
East Asian People
Female
Humans
Hyaluronoglucosaminidase*
Pregnancy
Pregnant Women

Substances

Hyaluronoglucosaminidase
Ceramides