Surgical indications for solid hepatic benign tumors: An updated literature review

Biosci Trends. 2023 Nov 18;17(5):325-334. doi: 10.5582/bst.2023.01152. Epub 2023 Aug 19.


Hepatic hemangioma, focal nodular hyperplasia, and hepatic adenoma are the most common benign solid liver tumors. However, their surgical indications have been the subject of debate. Minimally invasive liver resection reduces the cost of surgery and may lead to overtreatment of benign liver tumors. Recently, there has been a growing understanding of the etiology, pathogenesis, and natural history of these tumors. Great progress has also been made in imaging. The use of MRI and contrast agents has improved the accuracy of non-invasive diagnosis of these tumors, and especially in the identification of specific molecular subtypes of liver adenoma. These factors have resulted in alterations of surgical indications for these tumors. This article examines recent literature and it discusses the surgical indications for hepatic hemangioma, focal nodular hyperplasia, and hepatic adenoma while summarizing modifications in clinical management.

Keywords: benign liver tumors; management; surgery.

Publication types

  • Review

MeSH terms

  • Adenoma, Liver Cell* / diagnosis
  • Adenoma, Liver Cell* / pathology
  • Adenoma, Liver Cell* / surgery
  • Focal Nodular Hyperplasia* / diagnostic imaging
  • Focal Nodular Hyperplasia* / surgery
  • Hemangioma* / diagnostic imaging
  • Hemangioma* / surgery
  • Humans
  • Liver / diagnostic imaging
  • Liver / pathology
  • Liver / surgery
  • Liver Neoplasms* / diagnostic imaging
  • Liver Neoplasms* / surgery