Diabetes-associated neutrophil NETosis: pathogenesis and interventional target of diabetic complications

Yuyan Zhu; Xuan Xia; Qian He; Qing-Ao Xiao; Decheng Wang; Meirong Huang; Xiaolin Zhang

doi:10.3389/fendo.2023.1202463

Diabetes-associated neutrophil NETosis: pathogenesis and interventional target of diabetic complications

Front Endocrinol (Lausanne). 2023 Aug 3:14:1202463. doi: 10.3389/fendo.2023.1202463. eCollection 2023.

Authors

Yuyan Zhu^{1

2

3}, Xuan Xia^{1

2

3

4}, Qian He⁵, Qing-Ao Xiao^{6

7}, Decheng Wang^{1

2

3}, Meirong Huang^{1

2

3

4}, Xiaolin Zhang^{6

7}

Affiliations

¹ College of Basic Medical Science, China Three Gorges University, Yichang, China.
² Institute of Infection and Inflammation, China Three Gorges University, Yichang, China.
³ Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, China.
⁴ Department of Physiology and Pathophysiology, College of Basic Medical Science, China Three Gorges University, Yichang, China.
⁵ National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
⁶ Department of Interventional Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, China.
⁷ Department of Interventional Radiology, Yichang Central People's Hospital, Yichang, Hubei, China.

Abstract

Neutrophil extracellular traps (NETs) are known as extracellular fibers networks consisting of antimicrobial proteins and decondensated chromatin DNA released by activated neutrophils. NETosis is a NETs-induced neutrophilic cell death which is unique from necrosis or apoptosis. Besides its neutralizing pathogen, NETosis plays a crucial role in diabetes and diabetes-related complications. In patients with diabetes, NETs-releasing products are significantly elevated in blood, and these findings confirm the association of NETosis and diabetic complications, including diabetic wound healing, diabetic retinopathy, and atherosclerosis. This article briefly summarizes the mechanisms of NETosis and discusses its contribution to the pathogenesis of diabetes-related complications and suggests new therapeutic targets by some small molecule compounds.

Keywords: NETosis; diabetes mellitus; diabetic complications; inflammation; neutrophil.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis
Atherosclerosis*
Diabetes Mellitus* / etiology
Diabetic Retinopathy*
Extracellular Traps*
Humans
Neutrophils

Grants and funding

This work was funded by grants from Hubei Natural Science Foundation (2015CFB316) and National Natural Science Foundation of China (No. 82100473).