Immunology: NACHT domain proteins get a prokaryotic origin story

Curr Biol. 2023 Aug 21;33(16):R875-R878. doi: 10.1016/j.cub.2023.06.084.


The NACHT domain is found in eukaryotic pattern recognition receptors that promote anti-microbial defense, mediating their oligomerization into immune signaling complexes. Kibby et al. uncover a superfamily of prokaryotic NACHT-containing proteins and demonstrate that some members of this family mediate anti-phage defense.

Publication types

  • Comment

MeSH terms

  • Bacteriophages* / genetics
  • Eukaryota
  • Eukaryotic Cells
  • Prokaryotic Cells
  • Signal Transduction