Red blood cells: a potential delivery system

J Nanobiotechnology. 2023 Aug 22;21(1):288. doi: 10.1186/s12951-023-02060-5.


Red blood cells (RBCs) are the most abundant cells in the body, possessing unique biological and physical properties. RBCs have demonstrated outstanding potential as delivery vehicles due to their low immunogenicity, long-circulating cycle, and immune characteristics, exhibiting delivery abilities. There have been several developments in understanding the delivery system of RBCs and their derivatives, and they have been applied in various aspects of biomedicine. This article compared the various physiological and physical characteristics of RBCs, analyzed their potential advantages in delivery systems, and summarized their existing practices in biomedicine.

Keywords: Bioimaging; Delivery system; Red blood cells; Therapeutic strategies.

Publication types

  • Review

MeSH terms

  • Drug Delivery Systems*
  • Erythrocytes*